HCID 70112767, compound → HCID 70112512, compound

HRID 324447Notes

Reaction equation

HRID 324447 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:15]([C:17]3[C:18](=[O:25])[NH:19][C:20](=[O:24])[N:21]([CH3:23])[CH:22]=3)(O)[C:10]3[N:11]=[C:12]([CH3:14])[O:13][C:9]=3[CH2:8][CH2:7][C:6]=2[CH:26]=1>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:15]([C:17]3[C:18](=[O:25])[NH:19][C:20](=[O:24])[N:21]([CH3:23])[CH:22]=3)[C:10]3[N:11]=[C:12]([CH3:14])[O:13][C:9]=3[CH:8]=[CH:7][C:6]=2[CH:26]=1

Participants

3

Reactant 1

HCID 70112767HCID 70112767, compound

Product 1

HCID 70112512HCID 70112512, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of the product from step (viii) (0.85 g) in trifluoroacetic acid (20 ml) was heated at reflux for 8 days. The solvent was evaporated and the residue triturated with ethyl acetate/isohexane to give a solid.

Workup

  1. temperatureat reflux for 8 days
  2. customThe solvent was evaporated
  3. customthe residue triturated with ethyl acetate/isohexane
  4. customto give a solid

Sources & evidence

ORD record
ord-fc88a5ad26b44047af7a257655f126f1
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

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