Acetone → HCID 69307971, compound

HRID 32445Notes

Reaction equation

HRID 32445 reaction equation
Cl.[C:2]1([C@@H:8]([NH:18][C:19](=[O:28])[O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:9][O:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:29][C:30]([CH3:32])=O>>[CH:30]([N:15]1[CH2:16][CH2:17][CH:12]([CH2:11][O:10][CH2:9][C@H:8]([NH:18][C:19](=[O:28])[O:20][CH2:21][C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:13][CH2:14]1)([CH3:32])[CH3:29]

Participants

3

Reactant 2

HCID 180AcetoneHCID 69308036HCID 69308036, compound

Product 1

HCID 69307971HCID 69307971, compound

Procedure

Using alkylation method A, benzyl N-[(R)-1-phenyl-2-(piperidin-4-ylmethoxy)ethyl]carbamate hydrochloride (3.7 g, 0.91 mmol) and acetone (2.3 g, 40 mmol) afforded, after purification (SiO2: 8:2:1 hexane:EtOAc:isopropylamine), 1.1 g (29%) of the title compound.

Workup

  1. customafforded
  2. customafter purification (SiO2: 8:2:1 hexane:EtOAc:isopropylamine), 1.1 g (29%) of the title compound

Sources & evidence

ORD record
ord-7969cd7c5a004d4c8fbde99400d76f86
Source dataset
uspto-grants-2008_09
Patent number
US07427632B2

Reaction notes

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