Methyl iodide → HCID 178437540, compound

HRID 324453Notes

Reaction equation

HRID 324453 reaction equation
CI.[CH2:3]([C:5]1[S:6][C:7]2[CH:14]=[CH:13][C:12]3[CH:15]=[C:16]([CH3:19])[CH:17]=[CH:18][C:11]=3[CH:10]([C:20]3[C:21](=[S:27])[NH:22][C:23](=[O:26])[NH:24][CH:25]=3)[C:8]=2[N:9]=1)[CH3:4].[C:28](=O)(O)[O-].[Na+]>C(O)C.O>[CH2:3]([C:5]1[S:6][C:7]2[CH:14]=[CH:13][C:12]3[CH:15]=[C:16]([CH3:19])[CH:17]=[CH:18][C:11]=3[CH:10]([C:20]3[C:21]([S:27][CH3:28])=[N:22][C:23](=[O:26])[NH:24][CH:25]=3)[C:8]=2[N:9]=1)[CH3:4]

Participants

6

Reactant 3

HCID 6328Methyl iodideHCID 516892Sodium BicarbonateHCID 88151944HCID 88151944, compound

Product 1

HCID 178437540HCID 178437540, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Methyl iodide (0.044 ml) was added to a stirred solution of the product from example 31 step (v) (0.250 g) and sodium bicarbonate (0.057 g) in ethanol (5 ml) and water (3 ml). After 3 h the reaction mixture was partitioned between ethyl acetate and water. The organic phase was washed with water, dried (MgSO4) and evaporated under reduced pressure. Purification was by trituration with ethyl acetate and isohexane.

Workup

  1. customAfter 3 h the reaction mixture was partitioned between ethyl acetate and water
  2. washThe organic phase was washed with water
  3. dry with materialdried (MgSO4)
  4. customevaporated under reduced pressure
  5. customPurification

Sources & evidence

ORD record
ord-4f3e85d924814e2aada917635b64268b
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

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