Lawesson's reagent → HCID 178432307, compound

HRID 324481Notes

Reaction equation

HRID 324481 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:22]([C:23]3[C:24](=O)[NH:25][C:26](=[O:30])[N:27]([CH3:29])[CH:28]=3)[C:10]3[N:11]=[C:12]([CH3:21])[N:13]([CH2:14][CH2:15][C:16]4[N:17]=[CH:18][NH:19][CH:20]=4)[C:9]=3[CH:8]=[CH:7][C:6]=2[CH:32]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:42])=CC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:22]([C:23]3[C:24](=[S:42])[NH:25][C:26](=[O:30])[N:27]([CH3:29])[CH:28]=3)[C:10]3[N:11]=[C:12]([CH3:21])[N:13]([CH2:14][CH2:15][C:16]4[N:17]=[CH:18][NH:19][CH:20]=4)[C:9]=3[CH:8]=[CH:7][C:6]=2[CH:32]=1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 178432306HCID 178432306, compound

Product 1

HCID 178432307HCID 178432307, compound

Procedure

The title compound was prepared from the product of step (iii) (0.2 g) and Lawesson's reagent (0.9 g) according to the method of example 34 step (iv). Purification was by biotage chromatography on silica eluting with 5% methanol in dichloromethane with 1% 0.880 ammonia present to give a yellow glass.

Workup

  1. customPurification
  2. customto give a yellow glass

Sources & evidence

ORD record
ord-627cecf10c274e4dae8275e0e87f3d8c
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

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