huagongshe.com
HRID32449

反应详情

EQUATION

反应方程式

HRID 32449 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)c1cc2cc(Cl)ccc2[nH]1
HCID82693

5-Chloroindole-2-carboxylate

C9H6ClNO2

结构：CC(C)N1CCC(COC[C@H](N)c2ccccc2)CC1
HCID69309716

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)N1CCC(COC[C@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)c2ccccc2)CC1.Cl
HCID69310602

未命名化合物

PROCEDURE

实验过程

Using coupling method A, (R)-2-(1-isopropylpiperidin-4-ylmethoxy)-1-phenylethylamine (200 mg, 0.73 mmol) and 5-chloroindole-2-carboxylic acid (142 mg, 0.75 mmol) afforded, after purification (SiO2: 4:2:1 DCM:EtOAc:isopropylamine) and conversion to the HCl salt by general method A, 320 mg (92%) of the title compound.

WORKUP

后处理

  1. customafforded
  2. customafter purification (SiO2: 4:2:1 DCM:EtOAc:isopropylamine) and conversion to the HCl salt by general method A, 320 mg (92%) of the title compound