5-Chloro-1H-indole-2-carboxylic acid → 5-Chloro-N-[(R)-2-(1-isopropylpiperidine-4-ylmethoxy)-1-phenylethyl]-1H-indole-2-carboxamide hydrochloride

Participants

Reaction Steps

Using coupling method A, (R)-2-(1-isopropylpiperidin-4-ylmethoxy)-1-phenylethylamine (200 mg, 0.73 mmol) and 5-chloroindole-2-carboxylic acid (142 mg, 0.75 mmol) afforded, after purification (SiO2: 4:2:1 DCM:EtOAc:isopropylamine) and conversion to the HCl salt by general method A, 320 mg (92%) of the title compound.

Provenance & Evidence