1-Methyluracil → (+/-)-5-(2,7-Dichloro-4H-benzo[5,6]cyclohepta[1,2-d]thiazol-4-yl)-1-methyl-2,4(1H,3H)-pyrimidinedione

HRID 324491Notes

Reaction equation

HRID 324491 reaction equation
[Cl:1][C:2]1[S:3][C:4]2[CH:11]=[CH:10][C:9]3[CH:12]=[C:13]([Cl:16])[CH:14]=[CH:15][C:8]=3[CH:7](O)[C:5]=2[N:6]=1.[CH3:18][N:19]1[CH:26]=[CH:25][C:23](=[O:24])[NH:22][C:20]1=[O:21]>>[Cl:1][C:2]1[S:3][C:4]2[CH:11]=[CH:10][C:9]3[CH:12]=[C:13]([Cl:16])[CH:14]=[CH:15][C:8]=3[CH:7]([C:25]3[C:23](=[O:24])[NH:22][C:20](=[O:21])[N:19]([CH3:18])[CH:26]=3)[C:5]=2[N:6]=1

Participants

3

Reactant 2

HCID 120091-MethyluracilHCID 70113755(+/-)-2,7-Dichloro-4H-benzo[5,6]cyclohepta[1,2-d]thiazol-4-ol

Product 1

HCID 70113243(+/-)-5-(2,7-Dichloro-4H-benzo[5,6]cyclohepta[1,2-d]thiazol-4-yl)-1-methyl-2,4(1H,3H)-pyrimidinedione

Procedure

The title product was prepared from the product of step (vii) (1.27 g) and 1-methyluracil (1 g) according to the method of example 38 step (iv). Purification was by chromatography eluting with 50-60% ethyl acetate in isohexane.

Workup

  1. customPurification
  2. washeluting with 50-60% ethyl acetate in isohexane

Sources & evidence

ORD record
ord-744ec6c68d764b288fbf9440f9c575a7
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

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