反应详情

The product from example 44 step (viii) (0.05 g) was heated with 0.88 ammonia (2 ml) and ethanol (1 ml) in a sealed tube at 100° C. for 24 h. The volatiles were removed under reduced pressure and the residue triturated with ethyl acetate and methanol mixtures to leave the title product as a yellow solid.

1. customThe volatiles were removed under reduced pressure
2. customthe residue triturated with ethyl acetate and methanol mixtures