Ammonia → (+/-)-5-(2-Amino-7-chloro-4H-benzo[5,6]cyclohepta[1,2-d]thiazol-4-yl)-1-methyl-2,4(1H,3H)-pyrimidinedione

Participants

Reaction Steps

The product from example 44 step (viii) (0.05 g) was heated with 0.88 ammonia (2 ml) and ethanol (1 ml) in a sealed tube at 100° C. for 24 h. The volatiles were removed under reduced pressure and the residue triturated with ethyl acetate and methanol mixtures to leave the title product as a yellow solid.

Provenance & Evidence