Dimethyl Sulfoxide → HCID 88151508, compound

Participants

Role	Name	HCID	Charge
Reactant	Dimethyl Sulfoxide	HCID 679	—
Reactant	Benzylamine	HCID 7504	—
Reactant	(+/-)-5-(2,7-Dichloro-4H-benzo[5,6]cyclohepta[1,2-d]thiazol-4-yl)-1-methyl-2,4(1H,3H)-pyrimidinedione	HCID 70113243	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	HCID 88151508	HCID 88151508	—

Reaction Conditions

Temperature	60 °C

Reaction Steps

A mixture of the product from example 44 step (viii) (0.25 g) and benzylamine (0.14 ml) in dry 1,4-dioxane (3 ml) were heated at 60° C. for 36 h. After this time benzylamine (0.14 ml) and dry dimethylsulphoxide (2 ml) were added and the mixture was heated at 60° C. for a further 72 h. The solvent was removed under reduced pressure. Purification was by trituration with diethyl ether and water.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06218376B1
Source dataset	uspto-grants-2001_04
ORD ID	ord-59a423c0842a4a35a9dbdbf11a4cbaf2
Source note	uspto-grants-2001_04