HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 324506Generated: October 30, 2026
Cyclobutylamine → HCID 88151603, compound
https://huagongshe.com/reaction/324506
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclobutylamine | HCID 75645 | — |
| Reactant | (+/-)-5-(2,7-Dichloro-4H-benzo[5,6]cyclohepta[1,2-d]thiazol-4-yl)-1-methyl-2,4(1H,3H)-pyrimidinedione | HCID 70113243 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 88151603 | HCID 88151603 | — |
Reaction Steps
A mixture of the product from example 44 step (viii) (0.25 g) and cyclobutylamine (0.54 ml) in dry 1,4-dioxane (3 ml) were heated at 60° C. for 34 h. The solvent was removed under reduced pressure and the residue partitioned between water and ethyl acetate. The organic extracts were dried (MgSO4) and evaporated under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06218376B1 |
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| Source dataset | uspto-grants-2001_04 |
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| ORD ID | ord-f6621522326b4fed9a47ff5a85177132 |
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| Source note | uspto-grants-2001_04 |
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