Cyclobutylamine → HCID 88151603, compound

HRID 324506Notes

Reaction equation

HRID 324506 reaction equation
Cl[C:2]1[S:3][C:4]2[CH:11]=[CH:10][C:9]3[CH:12]=[C:13]([Cl:16])[CH:14]=[CH:15][C:8]=3[CH:7]([C:17]3[C:18](=[O:25])[NH:19][C:20](=[O:24])[N:21]([CH3:23])[CH:22]=3)[C:5]=2[N:6]=1.[CH:26]1([NH2:30])[CH2:29][CH2:28][CH2:27]1>O1CCOCC1>[Cl:16][C:13]1[CH:14]=[CH:15][C:8]2[CH:7]([C:17]3[C:18](=[O:25])[NH:19][C:20](=[O:24])[N:21]([CH3:23])[CH:22]=3)[C:5]3[N:6]=[C:2]([NH:30][CH:26]4[CH2:29][CH2:28][CH2:27]4)[S:3][C:4]=3[CH:11]=[CH:10][C:9]=2[CH:12]=1

Participants

4

Reactant 2

HCID 75645CyclobutylamineHCID 70113243(+/-)-5-(2,7-Dichloro-4H-benzo[5,6]cyclohepta[1,2-d]thiazol-4-yl)-1-methyl-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 88151603HCID 88151603, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of the product from example 44 step (viii) (0.25 g) and cyclobutylamine (0.54 ml) in dry 1,4-dioxane (3 ml) were heated at 60° C. for 34 h. The solvent was removed under reduced pressure and the residue partitioned between water and ethyl acetate. The organic extracts were dried (MgSO4) and evaporated under reduced pressure.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe residue partitioned between water and ethyl acetate
  3. dry with materialThe organic extracts were dried (MgSO4)
  4. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-f6621522326b4fed9a47ff5a85177132
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

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