Cyclopropylamine → HCID 88151771, compound

HRID 324507Notes

Reaction equation

HRID 324507 reaction equation
Cl[C:2]1[S:3][C:4]2[CH:11]=[CH:10][C:9]3[CH:12]=[C:13]([Cl:16])[CH:14]=[CH:15][C:8]=3[CH:7]([C:17]3[C:18](=[O:25])[NH:19][C:20](=[O:24])[N:21]([CH3:23])[CH:22]=3)[C:5]=2[N:6]=1.[CH:26]1([NH2:29])[CH2:28][CH2:27]1>O1CCOCC1>[Cl:16][C:13]1[CH:14]=[CH:15][C:8]2[CH:7]([C:17]3[C:18](=[O:25])[NH:19][C:20](=[O:24])[N:21]([CH3:23])[CH:22]=3)[C:5]3[N:6]=[C:2]([NH:29][CH:26]4[CH2:28][CH2:27]4)[S:3][C:4]=3[CH:11]=[CH:10][C:9]=2[CH:12]=1

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 70113243(+/-)-5-(2,7-Dichloro-4H-benzo[5,6]cyclohepta[1,2-d]thiazol-4-yl)-1-methyl-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 88151771HCID 88151771, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of the product from example 44 step (viii) (0.25 g) and cyclopropylamine (0.44 ml) in dry 1,4-dioxane (3 ml) was heated at 100° C. for 34 h. The solvent was removed under reduced pressure and the residue partitioned between water and ethyl acetate. The organic extracts were dried (MgSO4) and evaporated under reduced pressure.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe residue partitioned between water and ethyl acetate
  3. dry with materialThe organic extracts were dried (MgSO4)
  4. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-8e35d169a83c4414adccbf7d250b2704
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

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