HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 324507Generated: October 30, 2026
Cyclopropylamine → HCID 88151771, compound
https://huagongshe.com/reaction/324507
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | (+/-)-5-(2,7-Dichloro-4H-benzo[5,6]cyclohepta[1,2-d]thiazol-4-yl)-1-methyl-2,4(1H,3H)-pyrimidinedione | HCID 70113243 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 88151771 | HCID 88151771 | — |
Reaction Steps
A mixture of the product from example 44 step (viii) (0.25 g) and cyclopropylamine (0.44 ml) in dry 1,4-dioxane (3 ml) was heated at 100° C. for 34 h. The solvent was removed under reduced pressure and the residue partitioned between water and ethyl acetate. The organic extracts were dried (MgSO4) and evaporated under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06218376B1 |
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| Source dataset | uspto-grants-2001_04 |
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| ORD ID | ord-8e35d169a83c4414adccbf7d250b2704 |
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| Source note | uspto-grants-2001_04 |
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