Ethanolamine → 7-Chloro-1-(2-hydroxyethyl)-2-methyl-4H-benzo[5,6]cyclohepta[1,2-d]imidazol-4-one

Participants

Role	Name	HCID	Charge
Reactant	Ethanolamine	HCID 700	—
Reactant	7-Chloro-2-methyl-4H-benzo[5,6]cyclohepta[1,2-d]oxazol-4-one	HCID 22003622	—
Solvent	Water	HCID 962	—
Product	7-Chloro-1-(2-hydroxyethyl)-2-methyl-4H-benzo[5,6]cyclohepta[1,2-d]imidazol-4-one	HCID 22003591	—

Reaction Conditions

Temperature	90 °C

Reaction Steps

A mixture of the product from example 42 step (i) (1 g) and ethanolamine (10 ml) was stirred at 90° C. for 14 hours. The mixture was diluted with water (10 ml) and the solid filtered. The solid was further washed with water and then dichloromethane to leave the subtitle product as a beige powder.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06218376B1
Source dataset	uspto-grants-2001_04
ORD ID	ord-802f1c12dca14b5abd65f321a199d003
Source note	uspto-grants-2001_04