1-Methyluracil → (+/-)-5-(7-Chloro-1-(2-hydroxyethyl)-2-methyl-4h-benzo[5,6]cyclohepta-[1,2-d]imidazol-4-yl)-1-methyl-2,4(1h,3h)-pyrimidinedione

Participants

Role	Name	HCID	Charge
Reactant	1-Methyluracil	HCID 12009	—
Reactant	(+/-)-7-Chloro-1-(2-hydroxyethyl)-2-methyl-4h-benzo[5,6]cyclohepta[1,2-d]imidazol-4-ol	HCID 22003582	—
Product	(+/-)-5-(7-Chloro-1-(2-hydroxyethyl)-2-methyl-4h-benzo[5,6]cyclohepta-[1,2-d]imidazol-4-yl)-1-methyl-2,4(1h,3h)-pyrimidinedione	HCID 22003662	—

Reaction Steps

The subtitle compound was prepared from the product from step (ii) (1.85 g) and 1-methyluracil (0.4 g) according to the method of example 42 step (iv). Purification was by biotage chromatography on silica eluting with 5% methanol in dichloromethane with 1% 0.880 ammonia present.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06218376B1
Source dataset	uspto-grants-2001_04
ORD ID	ord-df551c760b614135aa42c1b5a6e35bde
Source note	uspto-grants-2001_04