Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Butanone, 1-phenyl-4-(4-pyridinyl)- | HCID 265173 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 85980352 | HCID 85980352 | 95.7% |
Reaction Steps
To a solution of 1-phenyl-4-(pyridin-4-yl)butan-1-one (2.0 g, 8.7 mmol) in 20 mL of EtOH was added hydroxylamine hydrochloride (0.73 g, 10 mmol) and sodium acetate (1.4 g, 17 mmol). The reaction flask was heated at 80° C. for 4 h and was then cooled to room temperature. Addition of water and filtration of the resultant precipitate afforded 2.0 g (89%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07427632B2 |
|---|
| Source dataset | uspto-grants-2008_09 |
|---|
| ORD ID | ord-48d2c45886ca45d1be1716d61216c655 |
|---|
| Source note | uspto-grants-2008_09 |
|---|
