Water → HCID 85980352, compound

HRID 32454Notes

Reaction equation

HRID 32454 reaction equation
[C:1]1([C:7](=O)[CH2:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:19][OH:20].C([O-])(=O)C.[Na+].O>CCO>[C:1]1([C:7](=[N:19][OH:20])[CH2:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 962WaterHCID 2651731-Butanone, 1-phenyl-4-(4-pyridinyl)-HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

Product 1

HCID 85980352HCID 85980352, compoundYield 95.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 1-phenyl-4-(pyridin-4-yl)butan-1-one (2.0 g, 8.7 mmol) in 20 mL of EtOH was added hydroxylamine hydrochloride (0.73 g, 10 mmol) and sodium acetate (1.4 g, 17 mmol). The reaction flask was heated at 80° C. for 4 h and was then cooled to room temperature. Addition of water and filtration of the resultant precipitate afforded 2.0 g (89%) of the title compound.

Workup

  1. temperaturewas then cooled to room temperature

Sources & evidence

ORD record
ord-48d2c45886ca45d1be1716d61216c655
Source dataset
uspto-grants-2008_09
Patent number
US07427632B2

Reaction notes

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