Acetone → N-[4-(1-Isopropylpiperidin-4-yl)-1-phenylbutyl]carbamic acid tert-butyl ester

HRID 32456Notes

Reaction equation

HRID 32456 reaction equation
[C:1]([O:5][C:6](=[O:24])[NH:7][CH:8]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:9][CH2:10][CH2:11][CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)([CH3:4])([CH3:3])[CH3:2].[CH3:25][C:26]([CH3:28])=O>>[C:1]([O:5][C:6](=[O:24])[NH:7][CH:8]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[CH2:9][CH2:10][CH2:11][CH:12]1[CH2:13][CH2:14][N:15]([CH:26]([CH3:28])[CH3:25])[CH2:16][CH2:17]1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 180AcetoneHCID 69308072N-[1-phenyl-4-(piperidine-4-yl)butyl]carbamic acid tert-butyl ester

Product 1

HCID 69310736N-[4-(1-Isopropylpiperidin-4-yl)-1-phenylbutyl]carbamic acid tert-butyl ester

Procedure

Using alkylation method A, crude N-[1-phenyl-4-(piperidine-4-yl)butyl]carbamic acid tert-butyl ester (0.70 mmol) and acetone (1.5 mL, 20 mmol) afforded the title compound as a crude residue that was used without further purification.

Sources & evidence

ORD record
ord-7252a629f6b54107b363f63d7f5a5807
Source dataset
uspto-grants-2008_09
Patent number
US07427632B2

Reaction notes

Loading…