反应详情

5 g (0.046 mol) of 3cyclopropyl-3-oxo-propanenitrile were dissolved in 200 ml of ethanol and 2.26 ml (0.046 mol) of hydrazine hydrate were added. The solution was maintained at reflux for 5 hours and then the solvent evaporated under vacuum. The residue was re-dissolved with methylene chloride and washed several times with brine. The organic layer was dried over anhydrous sodium sulfate and the solvent evaporated to give 4.53 g (80% yield) of the title compound.

1. temperatureThe solution was maintained
2. temperatureat reflux for 5 hours
3. customthe solvent evaporated under vacuum
4. dissolutionThe residue was re-dissolved with methylene chloride
5. washwashed several times with brine
6. dry with materialThe organic layer was dried over anhydrous sodium sulfate
7. customthe solvent evaporated