反应详情

温度

166 °C

4-Methoxybenzenethiol (X-1; 5 g, 0.0357 mol), diethyl ethoxymethylene malonate (7.3 ml) and sodium hydrogen sulfate monohydrate (100 mg) were heated with stirring in an oil bath at 166° C. for 2 h. After cooling, ice water was added to the reaction mixture and extracted with ether. The crude product was purified by silica gel (250 g) and ethyl acetate/hexane (1:4) to give compound (XI-1) (5.7 g, 51%) as an oil. NMR(CDCl3):1.29(3H,t, J=7.1), 1.38(3H, t, J=7.1), 3.83(3H, s), 4.23(2H, q, J=7.1), 4.35(2H, q, J=7.1), 6.93, 7.45(4H, AB, J=8.8), 8.30(1H,s)

1. temperatureAfter cooling
2. extractionextracted with ether
3. customThe crude product was purified by silica gel (250 g) and ethyl acetate/hexane (1:4)
4. customto give compound (XI-1) (5.7 g, 51%) as an oil