反应详情

温度

70 °C

To a solution of 1-(4-isopropylpiperazin-1-yl)-4-phenylbutane-1,4-dione 4-oxime (625 mg, 2.0 mmol) in 10 mL of THF was slowly added lithium aluminum hydride (250 mg, 6.6 mmol). The reaction flask was heated at 70° C. for 4 h after which time the flask was cooled to 0 C and the reaction was quenched by slow addition of water and 1 N sodium hydroxide. The biphasic mixture was filtered through a pad of diatomaceous earth, and the filtered solution was concentrated to dryness to afford 536 mg (98%) of the title compound as a crude residue that was used without further purification.

1. temperaturewas cooled to 0 C
2. customthe reaction was quenched by slow addition of water and 1 N sodium hydroxide
3. filtrationThe biphasic mixture was filtered through a pad of diatomaceous earth
4. concentrationthe filtered solution was concentrated to dryness