化工社化工社 化学情報印刷レポート · 研究参考用
Water → HCID 22004807、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Phosphorus tribromide | HCID 24614 | — |
| 反応物 | (2,3-Dihydro-1-benzofuran-5-yl)methanol | HCID 2776158 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | HCID 22004807 | HCID 22004807 | 100.4% |
反応手順
To a solution of (2,3-dihydrobenzofuran-5-yl)methanol (29.0 g, 0.193 mol) in tetrahydrofuran (150 mL) was added phosphorous tribromide (34.8 g, 0.129 mol) under ice/salt-cooling. The mixture was stirred for 20 minutes and then poured into water. The mixture was extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and evaporated to afford the title compound (yield 27.6 g, 91%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06218429B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-cc34e4cf088d4593ac45e12470da6142 |
| 出典メモ | uspto-grants-2001_04 |