Water → HCID 22004807、化合物

HRID 324634ノート

反応式

HRID 324634 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10]O)=[CH:9][C:4]=2[CH2:3][CH2:2]1.P(Br)(Br)[Br:13].O>O1CCCC1>[Br:13][CH2:10][C:8]1[CH:7]=[CH:6][C:5]2[O:1][CH2:2][CH2:3][C:4]=2[CH:9]=1

参加物

5

反応物 3

HCID 962WaterHCID 24614Phosphorus tribromideHCID 2776158(2,3-Dihydro-1-benzofuran-5-yl)methanol

生成物 1

HCID 22004807HCID 22004807、化合物収率 100.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of (2,3-dihydrobenzofuran-5-yl)methanol (29.0 g, 0.193 mol) in tetrahydrofuran (150 mL) was added phosphorous tribromide (34.8 g, 0.129 mol) under ice/salt-cooling. The mixture was stirred for 20 minutes and then poured into water. The mixture was extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and evaporated to afford the title compound (yield 27.6 g, 91%).

後処理

  1. temperaturesalt-cooling
  2. extractionThe mixture was extracted with ethyl acetate
  3. washThe extract was washed with brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customevaporated

出典と根拠

ORDレコード
ord-cc34e4cf088d4593ac45e12470da6142
出典データセット
uspto-grants-2001_04
特許番号
US06218429B1

反応ノート

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