HCID 67483578, compound → HCID 54380933, compound

HRID 324850Notes

Reaction equation

HRID 324850 reaction equation
[CH:1]([C:4]1[C:9]([C:10](OCC)=[O:11])=[C:8]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:21])[C:7]([CH:22]=[CH:23][CH2:24][CH2:25][CH3:26])=[C:6]([CH:27]([CH3:29])[CH3:28])[N:5]=1)([CH3:3])[CH3:2]>C(OCC)(=O)C.CCCCCC>[CH:1]([C:4]1[C:9]([CH2:10][OH:11])=[C:8]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:21])[C:7]([CH:22]=[CH:23][CH2:24][CH2:25][CH3:26])=[C:6]([CH:27]([CH3:28])[CH3:29])[N:5]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 67483578HCID 67483578, compound

Product 1

HCID 54380933HCID 54380933, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The title compound was prepared from the intermediate obtained in Step A by the procedure described in Example 125, Step F. 1H NMR (300 MHz, CDCl3) (reported as a mixture of olefin isomers): δ 0.70 (t, J=7.5 Hz, 3 H), 1.10-1.40 (m, 15 H), 1.87 (tdd, J=7.5, 7.5, 1.5, 2 H), 1.95 (s, 3 H), 3.30-3.50 (m, 2 H), 4.20 (m, 1 H), 4.45 (m, 1 H), 5.30 (m, 1 H), 5.93 (m, 2 H), 6.90-7.30 (m, 4 H). FAB-MS: calculated for C24H33NO 352; found 352 (M+H, 100%). Rf=0.32 (10% ethyl acetate/n-hexane). mp 76-79° C.

Sources & evidence

ORD record
ord-1967016547e242bea7b9627fb4ba5483
Source dataset
uspto-grants-2001_04
Patent number
US06218431B1

Reaction notes

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