HCID 54469891, compound → HCID 22005166, compound

HRID 324855Notes

Reaction equation

HRID 324855 reaction equation
[CH:1]([C:4]1[C:9]([CH2:10][OH:11])=[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=2)[C:7]([CH:19]=[CH:20][CH2:21][CH2:22][CH3:23])=[C:6]([CH:24]([CH3:26])[CH3:25])[N:5]=1)([CH3:3])[CH3:2]>C(OCC)(=O)C.CCCCCC>[CH:1]([C:4]1[C:9]([CH2:10][OH:11])=[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=2)[C:7]([CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[C:6]([CH:24]([CH3:25])[CH3:26])[N:5]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 54469891HCID 54469891, compound

Product 1

HCID 22005166HCID 22005166, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The title compound was prepared from 2,6-diisopropyl-3-hydroxymethyl-4-(3-chlorophenyl)-5-(pent-1-enyl)pyridine (Example 145) by the procedure described in Example 126. 1H NMR (300 MHz, CDCl3): δ 0.80 (t, J=7.0 Hz, 3 H), 1.0-1.40 (m, 19 H), 2.26 (m, 2 H), 3.23 (m, 1 H) 3.41 (m, 1 H), 4.34 (m, 2 H), 7.05-7.45 (m, 4 H). FAB-MS: calculated for C23H32NOCl 374; found 374 (M+H, 100%). Rf0.26 (10% ethyl acetate/n-hexane). mp 94-95° C.

Sources & evidence

ORD record
ord-ee17c80b71544d79b94bc9fc1688141c
Source dataset
uspto-grants-2001_04
Patent number
US06218431B1

Reaction notes

Loading…