Methyl iodide → 6-Chloro-1-methyl-2(1H)pyridinone

HRID 324964Notes

Reaction equation

HRID 324964 reaction equation
[Cl:1][C:2]1[NH:3][C:4](=[O:8])[CH:5]=[CH:6][CH:7]=1.[CH3:9]I>>[Cl:1][C:2]1[N:3]([CH3:9])[C:4](=[O:8])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 856216-Chloro-2-pyridinol

Product 1

HCID 1402016-Chloro-1-methyl-2(1H)pyridinone

Procedure

51.82 g of 2-chloro-pyrid-6-one (400 mmol) and 12.7. g of 83% sodium-hydride dispersion in mineral oil (440 mmol) are reacted in 400 ml absolute dimnethylfomamide at room temperature under argon for 15 minutes. 32.4 ml methyl-iodide (520 mmol) are added dropwise and stirring is continued at 50° for 5 hours. The reaction mixture is evaporated on a rotary evaporator until the solvent starts to distill from a bath of 60°.

Workup

  1. customThe reaction mixture is evaporated on a rotary evaporator until the solvent
  2. distillationto distill from a bath of 60°

Sources & evidence

ORD record
ord-a39f3d0d103f494498d6b47922e6f40a
Source dataset
uspto-grants-2001_04
Patent number
US06221870B1

Reaction notes

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