反应详情

Benzenesulfonyl chloride (0.62 g; 3.5 mmol) was added to a cold solution (ice:water temperature) of amino-3-[2-(4-cyanophenyl)ethylthio]benzene (0.80 g; 3.15 mmol; from step (ii) above) in a mixture of pyridine (1 mL) and CH2Cl2 (20 mL) over 10 minutes. After 3 hours stirring, 2M aqueous HCl was added and the solution extracted with CH2Cl2. The organic layer was dried (MgSO4) and the solvent removed in vacuo. The residue was purified by flash chromatography (SiO2; Et2O:hexane (1:1)) to give 1.02 g (82%) of the sub-title compound.

1. extractionthe solution extracted with CH2Cl2
2. dry with materialThe organic layer was dried (MgSO4)
3. customthe solvent removed in vacuo
4. customThe residue was purified by flash chromatography (SiO2; Et2O:hexane (1:1))