反应详情

10.0 g (44.2 mmol) of 2-amino-3-carboethoxy-4,5,6,7-tetra-hydrothieno[2,3-c)pyridine [sic] in 100 ml of toluene were mixed with 9.0 g (45 mM) of 1-phenyl-3-bromopropane, 400 mg of potassium iodide and 6.1 g (44.2 mmol) of finely powdered potassium carbonate and refluxed for 6 h. The residue after concentration in a rotary evaporator was taken up in water, adjusted to pH=10 and extracted twice with methylene chloride. The crude product after drying and concentration of the organic phase was extracted by stirring in 50 ml of isopropanol. The pale solid was filtered off with suction and washed with isopropanol. 7.8 g (51%) of product with melting point 108-110° C. were isolated.

1. temperaturerefluxed for 6 h
2. concentrationThe residue after concentration
3. customin a rotary evaporator
4. extractionextracted twice with methylene chloride
5. dry with materialThe crude product after drying
6. extractionconcentration of the organic phase was extracted
7. filtrationThe pale solid was filtered off with suction
8. washwashed with isopropanol