HCID 22002554, compound → HCID 22002550, compound

HRID 325092Notes

Reaction equation

HRID 325092 reaction equation
Br[CH:2]1[C:8](=O)[C:7]2[CH:10]=[C:11](F)[CH:12]=[CH:13][C:6]=2[S:5][CH2:4][CH2:3]1.[CH3:15][N:16]([CH3:33])[S:17]([NH:20][CH2:21][CH:22]1[CH2:27][CH2:26][CH:25]([CH2:28][NH:29][C:30]([NH2:32])=[S:31])[CH2:24][CH2:23]1)(=[O:19])=[O:18]>>[N:32]1[C:8]2[C:7]3[CH:10]=[CH:11][CH:12]=[CH:13][C:6]=3[S:5][CH2:4][CH2:3][C:2]=2[S:31][C:30]=1[NH:29][CH2:28][CH:25]1[CH2:26][CH2:27][CH:22]([CH2:21][NH:20][S:17]([N:16]([CH3:33])[CH3:15])(=[O:19])=[O:18])[CH2:23][CH2:24]1

Participants

3

Reactant 2

HCID 22002554HCID 22002554, compoundHCID 22253991HCID 22253991, compound

Product 1

HCID 22002550HCID 22002550, compound

Procedure

4-Bromo-7-fluoro-2,3,4,5-tetrahydro-1-benzothiepin-5-one (0.200 g, 0.720 mmole) and N-[4-([(dimethylamino)sulfonyl]aminomethyl)-cyclohexyl]methylthiourea (0.250 g, 0.810 mmole) were heated at reflux for 18 hours, the solvent removed under reduced pressure and the crude product chromatographed (silica) to afford N′-(4-[(4,5-dihydrobenzo[2,3]thiepino[4,5-d][1,3]thiazol-2-ylamino)methyl]cyclohexylmethyl)-N,N-dimethylsulfamide.

Workup

  1. temperatureat reflux for 18 hours
  2. customthe solvent removed under reduced pressure
  3. customthe crude product chromatographed (silica)

Sources & evidence

ORD record
ord-7aa0a6d9da7c402db09d1f590e8576a8
Source dataset
uspto-grants-2001_04
Patent number
US06222040B1

Reaction notes

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