反应详情

Methyl 4-chlorothieno[2,3-d]pyrimidine-6-carboxylate (intermediate 10) (114 mg), magnesium oxide (40 mg) and Pd/C (12 mg) in isopropanol (10 mL) were stirred under hydrogen for 48 hours. The solution was filtered through diatomaceous earth, washed with DCM (3×10 mL) and then concentrated in vacuo. Purification by flash chromatography on silica eluting with hexane:EtOAc (2:1) afforded the title compound as a white crystalline solid (76 mg, 78%);

1. filtrationThe solution was filtered through diatomaceous earth
2. washwashed with DCM (3×10 mL)
3. concentrationconcentrated in vacuo
4. customPurification by flash chromatography on silica eluting with hexane:EtOAc (2:1)