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温度

0 °C

To a solution of 2,2-dimethylpent-4-enal (11.2 g) in 200 mL of Et2O cooled to 0° C. was added dropwise a solution of benzylmagnesium chloride (70 mL, 2M in THF). After stirring for 1 h at 0° C., the reaction was quenched with 200 mL of saturated solution of NH4Cl and the product was extracted with 200 mL of 1:1 EtOAc/hexane. The extract was dried over Na2SO4 and concentrated. The residue was distilled under reduced pressure to give 16 g of the title compound.

1. customthe reaction was quenched with 200 mL of saturated solution of NH4Cl
2. extractionthe product was extracted with 200 mL of 1:1 EtOAc/hexane
3. dry with materialThe extract was dried over Na2SO4
4. concentrationconcentrated
5. distillationThe residue was distilled under reduced pressure