反应详情

Quinaldic acid (2.76 grams, 0.017 mole) was dissolved in 100 ml of dried tetrahydrofuran. Then 25 ml of 1.6 M (0.04 mole) of methyl lithium was added using a syringe. Reaction appeared immediate. The solution was stirred and heated under reflux for two hours and then poured into 600 ml of ice water. The ketone (2-acetylquinoline) was extracted with four 25 ml portions of ethyl ether which, after drying, was removed by rotary evaporation to yield ca. 1.0 g (ca. 40%) of 2-acetylquinoline.

1. customReaction
2. temperatureheated
3. temperatureunder reflux for two hours
4. extractionThe ketone (2-acetylquinoline) was extracted with four 25 ml portions of ethyl ether which
5. customafter drying
6. customwas removed by rotary evaporation