反应详情

A stirred solution of 21.5 g. (0.084 mole) of 3-methylthio-7-phenylindolin-2-one in 400 ml. of tetrahydrofuran was treated portionwise with 110 g. of a commercial Raney nickel/water slurry over a 3 hr. period. The mixture was filtered through Celite and the filtrate was concentrated to a gummy residue. The residue was recrystallized from cyclohexane-benzene to yield 7.6 g. (43%) of product as tan needles, m.p. 167°-169° C.

1. filtrationThe mixture was filtered through Celite
2. concentrationthe filtrate was concentrated to a gummy residue
3. customThe residue was recrystallized from cyclohexane-benzene
4. customto yield 7.6 g