Sodium methanethiolate → 6-Methyl-4-(methylthio)thieno[3,2-d]pyrimidine

HRID 32532Notes

Reaction equation

HRID 32532 reaction equation
[CH3:1][S-:2].[Na+].[CH3:4][C:5]1[S:13][C:12]2[C:11](Cl)=[N:10][CH:9]=[N:8][C:7]=2[CH:6]=1>C(#N)C>[CH3:4][C:5]1[S:13][C:12]2[C:11]([S:2][CH3:1])=[N:10][CH:9]=[N:8][C:7]=2[CH:6]=1

Participants

4

Reactant 2

HCID 4378561Sodium methanethiolateHCID 136832234-Chloro-6-methylthieno[3,2-d]pyrimidine

Product 1

HCID 179658316-Methyl-4-(methylthio)thieno[3,2-d]pyrimidineYield 97%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of sodium thiomethoxide (24S mg) and 6-methyl-4-chlorothieno[3,2-d]pyrimidine (Acta Pol. Pharm. (1986), 43(2), 97-100) (650 mg) in acetonitrile (50 mL) was stirred overnight. The mixture was filtered and the solid was washed with acetonitrile. The combined filtrate and washes were evaporated to give the title compound as a white solid (665 mg, 97%);

Workup

  1. filtrationThe mixture was filtered
  2. washthe solid was washed with acetonitrile
  3. customThe combined filtrate and washes were evaporated

Sources & evidence

ORD record
ord-bfa91bba01444c858e262522dcf3c6d5
Source dataset
uspto-grants-2008_09
Patent number
US07427616B2

Reaction notes

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