HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium methanethiolate → 6-Methyl-4-(methylthio)thieno[3,2-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Reactant | 4-Chloro-6-methylthieno[3,2-d]pyrimidine | HCID 13683223 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 6-Methyl-4-(methylthio)thieno[3,2-d]pyrimidine | HCID 17965831 | 97% |
Reaction Steps
A solution of sodium thiomethoxide (24S mg) and 6-methyl-4-chlorothieno[3,2-d]pyrimidine (Acta Pol. Pharm. (1986), 43(2), 97-100) (650 mg) in acetonitrile (50 mL) was stirred overnight. The mixture was filtered and the solid was washed with acetonitrile. The combined filtrate and washes were evaporated to give the title compound as a white solid (665 mg, 97%);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427616B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-bfa91bba01444c858e262522dcf3c6d5 |
| Source note | uspto-grants-2008_09 |