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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 32532Generated: October 27, 2026

Sodium methanethiolate → 6-Methyl-4-(methylthio)thieno[3,2-d]pyrimidine

https://huagongshe.com/reaction/32532

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium methanethiolateHCID 4378561—
Reactant4-Chloro-6-methylthieno[3,2-d]pyrimidineHCID 13683223—
SolventAcetonitrileHCID 6342—
Product6-Methyl-4-(methylthio)thieno[3,2-d]pyrimidineHCID 1796583197%

Reaction Steps

A solution of sodium thiomethoxide (24S mg) and 6-methyl-4-chlorothieno[3,2-d]pyrimidine (Acta Pol. Pharm. (1986), 43(2), 97-100) (650 mg) in acetonitrile (50 mL) was stirred overnight. The mixture was filtered and the solid was washed with acetonitrile. The combined filtrate and washes were evaporated to give the title compound as a white solid (665 mg, 97%);

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07427616B2
Source datasetuspto-grants-2008_09
ORD IDord-bfa91bba01444c858e262522dcf3c6d5
Source noteuspto-grants-2008_09