Hydrazine hydrate (1:1) → HCID 13059386, compound

HRID 325336Notes

Reaction equation

HRID 325336 reaction equation
C[O:2][C:3](=O)[C@H:4]([CH2:9][S:10][CH3:11])[NH:5][C:6](=[O:8])[CH3:7].O.[NH2:14][NH2:15]>C(O)C>[CH3:11][S:10][CH2:9][C@@H:4]([C:3]([NH:14][NH2:15])=[O:2])[NH:5][C:6](=[O:8])[CH3:7]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13059384HCID 13059384, compound

Product 1

HCID 13059386HCID 13059386, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 20 ml of ethanol were dissolved 1.70 g (8.9 mmole) of S-methyl-N-acetyl-L-cysteine methylester and 6 ml of aqueous 80% hydrazine hydrate solution and the solution was heated at reflux for 2 hours. After the reaction solution was concentrated in vacuo, a small amount of water was added to the residue and then distilled off in vacuo and this procedure was repeated three times to give white crystals. The crystals were washed with small amount of ethanol and dried to give 0.99 g (58% yield) of S-methyl-N-acetyl-cysteinylhydrazine.

Workup

  1. temperaturethe solution was heated
  2. temperatureat reflux for 2 hours
  3. concentrationAfter the reaction solution was concentrated in vacuo
  4. additiona small amount of water was added to the residue
  5. distillationdistilled off in vacuo
  6. customto give white crystals
  7. washThe crystals were washed with small amount of ethanol
  8. customdried

Sources & evidence

ORD record
ord-909a3e33c63240fcb4ba06541c85ad36
Source dataset
uspto-grants-1984_04
Patent number
US04440788

Reaction notes

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