反应详情

A solution of 2-[4-(2,3-epoxypropoxy)phenyl]trifluoromethylimidazole (2.5 g.) in tert. butylamine (20 ml.) is heated 6 hours at reflux. The excess tert. butylamine is removed by distillation at atmospheric pressure over steam. The residue is triturated with nitromethane (5 ml.) and the resulting solid removed by filtration. After recrystallization from acetonitrile, (1.2 g.) of 2-[4-(3-tert. butylamino-2-hydroxypropoxy)phenyl]-4-trifluoromethylimidazole is obtained, m.p. 185.5°-186.5° C.

1. temperatureat reflux
2. customThe excess tert. butylamine is removed by distillation at atmospheric pressure over steam
3. customThe residue is triturated with nitromethane (5 ml.)
4. customthe resulting solid removed by filtration
5. customAfter recrystallization from acetonitrile