反应详情

A solution of 2-[4-(2,3-epoxypropoxy)phenyl]-4-trifluoromethylimidazole in triethylamine (15 ml) is added 1.1 equivalents of a dimethylamine. This solution is refluxed until reaction is complete as indicated by TLC. The solvent is removed under reduced pressure and the residue recrystallized to yield 2-[4-(3-dimethylamino-2-hydroxypropoxy)phenyl]-4-trifluoromethylimidazole.

1. temperatureThis solution is refluxed until reaction
2. customThe solvent is removed under reduced pressure
3. customthe residue recrystallized