Hydrochloric Acid → HCID 13325939, compound

Participants

Reaction Steps

Ethyl 7-chloro-4,10 dihydro-1-methyl-10-oxo-1H-[1]benzothiepino[4,3-b]pyrrole-2-acetate (73 mg, 0.21 mmol) is dissolved in hot ethanol (2 ml) and 2.5 N aqueous sodium hydroxide (1 ml, 2.5 mmol) is added. The mixture is heated to 70° and stirred until it becomes homogeneous. Stirring is continued an additional fifteen minutes, then the mixture is cooled and treated with 2.5 N aqueous HCl (1.5 ml) to precipitate 58 mg (86%) of 7-chloro-4,10 dihydro-1-methyl-10-oxo-1H-[1]benzothiepino [4,3-b]pyrrole-2-acetic acid, m.p. 202° (dec).

Provenance & Evidence