Hydrochloric Acid → HCID 13325939, compound

HRID 325425Notes

Reaction equation

HRID 325425 reaction equation
[Cl:1][C:2]1[CH:23]=[CH:22][C:5]2[C:6](=[O:21])[C:7]3[N:8]([CH3:20])[C:9]([CH2:14][C:15]([O:17]CC)=[O:16])=[CH:10][C:11]=3[CH2:12][S:13][C:4]=2[CH:3]=1.[OH-].[Na+].Cl>C(O)C>[Cl:1][C:2]1[CH:23]=[CH:22][C:5]2[C:6](=[O:21])[C:7]3[N:8]([CH3:20])[C:9]([CH2:14][C:15]([OH:17])=[O:16])=[CH:10][C:11]=3[CH2:12][S:13][C:4]=2[CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 20464707HCID 20464707, compound

Product 1

HCID 13325939HCID 13325939, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 7-chloro-4,10 dihydro-1-methyl-10-oxo-1H-[1]benzothiepino[4,3-b]pyrrole-2-acetate (73 mg, 0.21 mmol) is dissolved in hot ethanol (2 ml) and 2.5 N aqueous sodium hydroxide (1 ml, 2.5 mmol) is added. The mixture is heated to 70° and stirred until it becomes homogeneous. Stirring is continued an additional fifteen minutes, then the mixture is cooled and treated with 2.5 N aqueous HCl (1.5 ml) to precipitate 58 mg (86%) of 7-chloro-4,10 dihydro-1-methyl-10-oxo-1H-[1]benzothiepino [4,3-b]pyrrole-2-acetic acid, m.p. 202° (dec).

Workup

  1. temperatureThe mixture is heated to 70°
  2. stirringStirring
  3. waitis continued an additional fifteen minutes
  4. temperaturethe mixture is cooled
  5. customto precipitate 58 mg (86%) of 7-chloro-4,10 dihydro-1-methyl-10-oxo-1H-[1]benzothiepino [4,3-b]pyrrole-2-acetic acid, m.p. 202° (dec)

Sources & evidence

ORD record
ord-d35ea7acbb5d4d18a1bad861850ee49b
Source dataset
uspto-grants-1984_04
Patent number
US04440779

Reaction notes

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