反应详情

To a methanolic solution (250 ml) of 4-chloroimidazo [1,5-a]quinoxaline 3-carboxylic acid ethyl ester (4 g) was added sodium bicarbonate (10 g) with stirring. The mixture was heated on steam bath for 2 hours. After removal of solvent under vacuum, the residue was taken up in water, then extracted with chloroform several times. The combined chloroform extracts were washed with water, dried by magnesium sulfate and evaporated to give the product as an off-white solid (2.2 g, 55% yield). Recrystallized from acetonitrile, m.p. 189°-191° C.

1. temperatureThe mixture was heated on steam bath for 2 hours
2. customAfter removal of solvent under vacuum
3. extractionextracted with chloroform several times
4. washThe combined chloroform extracts were washed with water
5. dry with materialdried by magnesium sulfate
6. customevaporated