Water → HCID 178470322, compound

HRID 325454Notes

Reaction equation

HRID 325454 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8](Br)[N:9]2[C:18]3[C:13](=[CH:14][C:15]([C:19]([F:22])([F:21])[F:20])=[CH:16][CH:17]=3)[N:12]([CH3:23])[C:11](=[O:24])[C:10]=12)=[O:5])[CH3:2].C([O-])(=[O:28])C.[K+].O>CS(C)=O>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([OH:28])[N:9]2[C:18]3[C:13](=[CH:14][C:15]([C:19]([F:22])([F:21])[F:20])=[CH:16][CH:17]=3)[N:12]([CH3:23])[C:11](=[O:24])[C:10]=12)=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 517044Potassium AcetateHCID 13309908HCID 13309908, compound

Product 1

HCID 178470322HCID 178470322, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

To a solution of 1-bromo-5-methyl-4-oxo-7-trifluoromethyl-4,5-dihydroimidazo[1,5-a]quinoxaline 3-carboxylic acid ethyl ester (3.2 g) in dimethylsulfoxide (DMSO) (30 ml) was added potassium acetate (2.5 g) with stirring. The mixture was heated on a steam bath for one hour. Water was then added to cause the precipitation of crude product as a white solid (2.3 g, 85% yield). Recrystallized from a mixture of acetonitrile, chloroform and methanol, m.p. >300° C.

Workup

  1. temperatureThe mixture was heated on a steam bath for one hour

Sources & evidence

ORD record
ord-51c7ccd16d6643eb8318975ee33a4802
Source dataset
uspto-grants-1984_04
Patent number
US04440929

Reaction notes

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