Hydrochloric Acid → HCID 178481345, compound

HRID 325457Notes

Reaction equation

HRID 325457 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8](Br)[N:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]([CH3:19])[C:11](=[O:20])[C:10]=12)=[O:5])C.Cl.[OH-:23].[Na+]>>[OH:23][C:8]1[N:9]2[C:18]3[C:13]([N:12]([CH3:19])[C:11](=[O:20])[C:10]2=[C:6]([C:4]([OH:3])=[O:5])[N:7]=1)=[CH:14][CH:15]=[CH:16][CH:17]=3

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 56614174HCID 56614174, compound

Product 1

HCID 178481345HCID 178481345, compoundYield 81%

Procedure

A mixture of 1-bromo-5-methyl-4-oxo-4,5-dihydroimidazo[1,5-a]quinoxaline 3-carboxylic acid ethyl ester (1.5 g) and 0.5 N sodium hydroxide solution (40 ml) was heated on steam bath for 18 hours. After cooling and acidification by concentrated hydrochloric acid, the product precipitated out as a cream colored solid (0.9 g, 81% yield), m.p. >300° C.

Workup

  1. temperaturewas heated on steam bath for 18 hours
  2. temperatureAfter cooling

Sources & evidence

ORD record
ord-24779837ce3e4355b678ab2d3ab26fd9
Source dataset
uspto-grants-1984_04
Patent number
US04440929

Reaction notes

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