反应详情

A suspension of 3-benzylamino-4-[3-(3-piperidinomethylphenoxy)propylamino]-1,2,5-thiadiazole 1-oxide (5.14 g; 11.3 mmoles) [prepared according to the procedure of U.S. Pat. No. 4,374,248] in 100 ml of methanol was treated with 7.55 ml of concentrated HCl. After stirring at ambient temperature for 3 hours, the solution was concentrated and the residue was triturated with acetone, filtered and dried to give 5.16 g (88%) of the title compound, mp 187°-205° C. (dec.).

1. customprepared
2. concentrationthe solution was concentrated
3. customthe residue was triturated with acetone
4. filtrationfiltered
5. customdried