Hydrochloric Acid → HCID 178478599, compound

HRID 325505Notes

Reaction equation

HRID 325505 reaction equation
[NH2:1][C:2]1[C:6]([NH:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]3[CH2:23][CH2:22][CH2:21][CH2:20]3)[CH:13]=2)=[N:5]S(=O)[N:3]=1.[ClH:25]>CO>[ClH:25].[ClH:25].[ClH:25].[N:19]1([CH2:18][C:14]2[CH:13]=[C:12]([CH:17]=[CH:16][CH:15]=2)[O:11][CH2:10][CH2:9][CH2:8][NH:7][C:6](=[NH:5])[C:2](=[NH:1])[NH2:3])[CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 159612053-Amino-4-[3-(3-pyrrolidinomethylphenoxy)propylamino]-1,2,5-thiadiazole 1-oxide

Product 1

HCID 178478599HCID 178478599, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 3-amino-4-[3-(3-pyrrolidinomethylphenoxy)propylamino]-1,2,5-thiadiazole 1-oxide (13.4 g; 38.3 mmoles) [prepared according to the procedure of U.S. Pat. No. 4,374,248] in 350 ml of methanol was treated with 25.5 mL of concentrated HCl. The resultant solution was stirred for 3 hours at ambiet temperature. Concentration of the solution followed by azeotropic removal of water with absolute ethanol gave the product. The crystalline residue was triturated with 150 mL of absolute ethanol, filtered and dried to give 10.8 g of the title compound, m.p. 195°-203° C. (dec.).

Workup

  1. customprepared
  2. customConcentration of the solution followed by azeotropic removal of water with absolute ethanol
  3. customgave the product
  4. customThe crystalline residue was triturated with 150 mL of absolute ethanol
  5. filtrationfiltered
  6. customdried

Sources & evidence

ORD record
ord-5c3ecd46c4a54375bf32370bf08f8010
Source dataset
uspto-grants-1984_04
Patent number
US04440933

Reaction notes

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