反应详情

A mixture of the product prepared in Step C in 50 ml of CH2Cl2 and 5.7 ml of triethylamine was treated with N,N'-thiobisphthalimide (DMF solvate) (5.44 g; 13.7 mmoles). After stirring at ambient temperature for one hour, the mixture was washed with 40 ml of 4 N NaOH, water, saturated aqueous NaCl solution, dried (Na2SO4), filtered and evaporated under reduced pressure to give the crude product. The product was purified by flash chromatography on 90 g of silica gel (230-400 mesh) using ethyl acetate-methanol (96:4) as the eluent to give 3.44 g of the title compound as a viscous oil. Treatment of the product with one equivalent of cyclohexyl sulfamic acid in acetone gave the cyclohexyl sulfamate of the title compound, mp 124.5°-126° C.

1. washthe mixture was washed with 40 ml of 4 N NaOH, water, saturated aqueous NaCl solution
2. dry with materialdried (Na2SO4)
3. filtrationfiltered
4. customevaporated under reduced pressure
5. customto give the crude product
6. customThe product was purified by flash chromatography on 90 g of silica gel (230-400 mesh)