Hydrochloric Acid → HCID 20464990, compound

HRID 325546Notes

Reaction equation

HRID 325546 reaction equation
[CH2:1]([NH:4][C:5]1[CH:6]=[C:7]([CH:15]=[CH:16][CH:17]=1)[CH2:8][CH2:9][C:10]([O:12]CC)=[O:11])[CH:2]=[CH2:3].[OH-].[K+].C(O)C.Cl>O>[CH2:1]([NH:4][C:5]1[CH:6]=[C:7]([CH:15]=[CH:16][CH:17]=1)[CH2:8][CH2:9][C:10]([OH:12])=[O:11])[CH:2]=[CH2:3]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 20465000HCID 20465000, compound

Product 1

HCID 20464990HCID 20464990, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A 4 g. sample of ethyl 3-(allylamino)hydrocinnamate is hydrolyzed with 1.6 g. 85% potassium hydroxide in 60 ml. 95% ethanol by refluxing the solution for 5 hours. The solution is cooled, diluted with 100 ml. water and acidified to pH 4.5 with 37% hydrochloric acid. The precipitate is collected, dried in vacuo and crystallized from acetone to yield the title compound as white powder.

Workup

  1. temperatureThe solution is cooled
  2. additiondiluted with 100 ml
  3. customThe precipitate is collected
  4. customdried in vacuo
  5. customcrystallized from acetone

Sources & evidence

ORD record
ord-78b6455e1a654165af1ba31b410169c0
Source dataset
uspto-grants-1984_04
Patent number
US04440940

Reaction notes

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