反应详情

To a mixture of 250 ml. of dichloromethane, 25 g. 1-hydroxyoctadec-9-ene and 16.7 g. of triethylamine cooled in an ice-salt bath to -10° C. is added dropwise, over 15 minutes, 18.9 g. of methanesulfonyl chloride. The mixture is cooled at -10° C. to -15° C. for 30 minutes and then washed with 300 ml. each of cold water, 10% hydrochloric acid, sodium carbonate solution and with saturated sodium chloride solution. The organic layer is dried with magnesium sulfate and concentrated in vacuo to give a pale yellow oil.

1. additionTo a mixture of 250 ml
2. additionis added dropwise, over 15 minutes
3. temperatureThe mixture is cooled at -10° C. to -15° C. for 30 minutes
4. washwashed with 300 ml
5. dry with materialThe organic layer is dried with magnesium sulfate
6. concentrationconcentrated in vacuo
7. customto give a pale yellow oil