Triethylamine → HCID 13217113, compound

Temperature

-5 °C

15.2 g of 2-benzyloxyethanol and 10.6 g of triethylamine were dissolved in 150 ml of toluene, and the solution was cooled to -5° C. A solution of 21.6 g of 2-bromopropionylbromide in 30 ml of toluene was added dropwise thereto at -5° to 0° C. with stirring. The reaction mixture was further maintained at room temperature for two hours. The mixture was then washed successively with 1% strength by weight sodium hydroxide solution and water, and the toluene solution was then dried and filtered. The toluene was distilled off under reduced pressure, and the end product of 2-benzyloxyethyl-2-bromopropionate was obtained in a yield of 26.7 g (nD20.5 1.5182)

1. temperatureThe reaction mixture was further maintained at room temperature for two hours
2. washThe mixture was then washed successively with 1% strength by weight sodium hydroxide solution and water
3. dry with materialthe toluene solution was then dried
4. filtrationfiltered
5. distillationThe toluene was distilled off under reduced pressure

ORD record

ord-1bd1eb9002224cee905dcf232639290d

Source dataset

uspto-grants-1984_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04441913